B-cell Acute Lymphoblastic Leukemia With t(9;22)(q34;q11) Translocation and Clonal Divergence Through ider(22) Chromosome and t(13;17)(q14;q25) Translocation

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B-cell Acute Lymphoblastic Leukemia With t(9;22)(q34;q11) Translocation and Clonal Divergence Through ider(22) Chromosome and t(13;17)(q14;q25) Translocation

Juan Pablo Meza-Espinoza, Ph.D., Enrique Jhonatan Romo Martínez, Ph.D., Lilia Aguilar López, M.D., Verónica Judith Picos Cárdenas, Ph.D., María Teresa Magaña Torres, Ph.D., and Juan Ramón González García, Ph.D. Facultad de Medicina e Ingeniería en Sistemas Computacionales, Universidad Autónoma de Tamaulipas, Matamoros, Tamaulipas; Ingeniería en Biotecnología, Universidad Politécnica de Sinaloa,...

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Acute leukemia with C-G chromosome translocation.

characterized by a specific chromosomal marker (the Philadelphia chromosome, Ph’), a significant percentage of all morphologic types of leukemia, except possibly chronic lymphocytic leukemia, will demonstrate aneuploidy. This report describes the occurrence of acute lymphocytic leukemia (ALL) in a young man with a balanced C-G translocation, t(Cp; Gp+), a rare chromosomal abnormality not previo...

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Pre-B cell leukemia associated with chromosome translocation 1;19.

Chromosome banding studies on 60 children with acute lymphocytic leukemia (ALL), including "null," pre-B, B, and T cell phenotypes, were performed. In 4 of 17 patients with pre-B cell ALL, we noted a previously undescribed chromosome translocation, t(1;19)(q23;q13). This translocation was not found in patients with "null" cell, B cell, or T cell ALL. Since each patient with the 1;19 translocati...

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Pre - B Cell Leukemia Associated With Chromosome Translocation

I N 1 978, a newly recognized type of acute leukemia, pre-B cell acute lymphocytic leukemia (ALL), was described.’ Recently, a remarkable difference in response to treatment has been noted between children with pre-B cell versus “null” (non-B, non-T, nonpre-B) cell ALL.2 The biologic basis for the relatively poor response to treatment of children with pre-B cell ALL is unclear. Both pre-B and “...

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RCSD1-ABL1 Translocation Associated with IKZF1 Gene Deletion in B-Cell Acute Lymphoblastic Leukemia

The RCSD1 gene has recently been identified as a novel gene fusion partner of the ABL1 gene in cases of B-cell Acute Lymphoblastic Leukemia (B-ALL). The RCSD1 gene is located at 1q23 and ABL1 is located at 9q34, so that the RCSD1-ABL1 fusion typically arises through a rare reciprocal translocation t(1;9)(q23;q34). Only a small number of RCSD1-ABL1 positive cases of B-ALL have been described in ...

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ژورنال

عنوان ژورنال: Annals of Laboratory Medicine

سال: 2016

ISSN: 2234-3806,2234-3814

DOI: 10.3343/alm.2016.36.2.185